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Specialty: Urology & Nephrology
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Total 114567 results found since Jan 2013.
Non-surgical management in children with non-refluxing primary megaureter: a systematic review and meta-analysis
ConclusionsThe low pooled prevalence of secondary surgical intervention and high pooled prevalence of resolution may support the current non-surgical management in children with non-refluxing primary megaureter. However, these results should be interpreted cautiously due to the limited available body of evidence. Future studies should overcome existing limitations of imaging methods by using standardized, comparable criteria and report outcome parameters in a quantitative manner. This would allow more sufficient data synthesis to provide evidence-based recommendations for clinical decision-making and counseling.Systematic ...
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research
The emerging role of the urinary microbiome in benign noninfectious urological conditions: an up-to-date systematic review
ConclusionThe study of the urogenital microbiome is rapidly expanding in urology. Noninfectious benign urogenital diseases, such as BPH, calcium oxalate stones, CPPS, and OAB were found to be associated with specific microbial taxonomies. Further research with larger study populations is necessary to solidify the knowledge of the urine microbiome in these conditions and to facilitate the creation of microbiome-based diagnostic and therapeutic approaches.
Source: World Journal of Urology - September 22, 2023 Category: Urology & Nephrology Source Type: research
The effect of exercise on vascular health in chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials
Am J Physiol Renal Physiol. 2023 Sep 21. doi: 10.1152/ajprenal.00152.2023. Online ahead of print.ABSTRACTPatients with chronic kidney disease (CKD) are at increased risk of cardiovascular disease. This increased risk cannot be fully explained by traditional risk factors such as hypertension. Endothelial dysfunction and arterial stiffness have been suggested as factors which explain some of the increased risk, and are independently associated with important cardiovascular outcomes in CKD patients. Studies in other disease populations have shown positive effects of exercise on vascular dysfunction. The aim of this review was...
Source: Am J Physiol Renal P... - September 21, 2023 Category: Urology & Nephrology Authors: Mark D Davies Felicity Hughes Aamer Sandoo Abdulfattah Alejmi Jamie Hugo Macdonald Source Type: research
Butylphthalide improves brain damage induced by renal ischemia-reperfusion injury rats through Nrf2/HO-1 and NOD2/MAPK/NF- κB pathways
This study demonstrates that NBP maintains BBB function by activating the Nrf2/HO-1 pathway and inhibiting the NOD2/MAPK/NF-κB pathway to suppress inflammation and oxidative stress, thereby alleviating renal I/R-induced brain injury.PMID:37732403 | DOI:10.1080/0886022X.2023.2259234
Source: Renal Failure - September 21, 2023 Category: Urology & Nephrology Authors: Jingjing Min Qi Chen Mengxiong Pan Tan Liu Qun Gu Dongwei Zhang Ru Sun Source Type: research
Comparison of young and old patients on peritoneal dialysis: A retrospective observational study
CONCLUSION: Peritonitis and technical survival evaluations of elderly PD patients, other than mortality, were lower than younger PD patients. However, the need for help is one of the biggest obstacles to this method for the elderly. We believe that incentives in this regard will increase the number of elderly PD patients.PMID:37734902 | DOI:10.1111/sdi.13180
Source: Seminars in Dialysis - September 21, 2023 Category: Urology & Nephrology Authors: Erdem Çankaya Murat Altunok Source Type: research
Health inequities in dialysis care: A scoping review
CONCLUSIONS: Our scoping review examined current literature on health inequities pertaining to dialysis and found gaps concerning LGBTQ+ and patients with lower levels of education. To help fill these gaps, and possibly alleviate additional burden to these patients, we recommend cultural competency training for providers and dialysis center staff as well as community-based educational programs to improve dialysis patients' health literacy.PMID:37734842 | DOI:10.1111/sdi.13176
Source: Seminars in Dialysis - September 21, 2023 Category: Urology & Nephrology Authors: Lindsey Kay Purcell Joseph William Schnitker Ty Michael Moore Andriana Mercedes Pe ña Mitchell Faris Love Alicia Ito Ford Benjamin Matt Vassar Source Type: research
The Significance of Hematuria in Podocytopathies
CONCLUSIONS: Hematuria is prevalent among participants with the three podocytopathies and is significantly and independently associated with worse kidney-related outcomes, including both progressive loss of kidney function remission of proteinuria.PMID:37733352 | DOI:10.2215/CJN.0000000000000309
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 21, 2023 Category: Urology & Nephrology Authors: Dorota Marchel Howard Trachtman Maria Larkina Margaret Helmuth Jennifer Y Lai Yee Damian Fermin Andrew S Bomback Pietro A Canetta Debbie S Gipson Amy K Mottl Rulan S Parekh Manish K Saha Matthew G Sampson Richard A Lafayette Laura H Mariani Nephrotic Synd Source Type: research
Green tea polyphenols alleviate kidney injury induced by di(2-ethylhexyl) phthalate in mice
CONCLUSION: GTP can alleviate DEHP-induced kidney damage and regulate immune cell infiltration. We screened four important miRNA-mRNA-protein regulatory axes of GTP mitigating DEHP-induced kidney damage in mice.PMID:37734331 | DOI:10.1159/000534106
Source: American Journal of Nephrology - September 21, 2023 Category: Urology & Nephrology Authors: Heng Shi Xinhai Zhao Peng Qin Xianling Zhou Sisi Liu Chuanchuan Sun Qiuyu Cao Shiping Zhu Shengyun Sun Source Type: research
Development and evaluation of the MiCheck ® Prostate test for clinically significant prostate cancer
CONCLUSIONS: The MiCheck® Prostate test identifies clinically significant prostate cancer with high sensitivity and negative predictive value (NPV). It can be performed in a clinical laboratory using a Roche Cobas clinical chemistry analyzer. The MiCheck® Prostate test could assist in reducing unnecessary prostate biopsies with a marginal number of patients experiencing a delayed diagnosis.PMID:37734979 | DOI:10.1016/j.urolonc.2023.08.005
Source: Urologic Oncology - September 21, 2023 Category: Urology & Nephrology Authors: Neal D Shore Dmitry M Polikarpov Christopher M Pieczonka R Jonathan Henderson James L Bailen Daniel R Saltzstein Raoul S Concepcion Jennifer L Beebe-Dimmer Julie J Ruterbusch Rachel A Levin Sandra Wissmueller Thao Ho Le David A Gillatt Daniel W Chan Niant Source Type: research
Kidney functional reserve, KFR, and damage biomarkers in subclinical chronic kidney disease complicated by acute kidney injury
Am J Physiol Renal Physiol. 2023 Sep 21. doi: 10.1152/ajprenal.00133.2023. Online ahead of print.ABSTRACTSignificant loss of kidney function is not easily identified by serum creatinine (sCr)-based measurements. In the presence of normal sCr, decreased KFR may identify significant loss of function. We evaluated KFR in experimental subclinical chronic kidney disease (sCKD) before and after brief ischemia-reperfusion injury (IRI). Using fluorescein isothiocyanate (FITC)-labelled sinistrin, GFR was measured transcutaneously before and after adenine induced sCKD, and 1 and 2 weeks after brief IRI, and compared with urinary kid...
Source: Am J Physiol Renal P... - September 21, 2023 Category: Urology & Nephrology Authors: Kylie M Taylor Amy Ym Au Sanjeeva Herath Lena Succar Jasmine Wong Jonathan Erlich Zoltan H Endre Source Type: research
Pharmacological inhibition of the MLL1-menin-interaction aggravates acute kidney injury induced by folic acid and ischemia/reperfusion in mice
In this study, we investigated the role and mechanisms of MLL1 in murine models of acute kidney injury (AKI) induced by folic acid (FA) and ischemia/reperfusion (I/R). Injury to the kidney elevated expression of MLL1, Menin, WDR5 and H3K4Me3, which was accompanied by increased serum creatinine (Scr) and blood urea nitrogen (BUN), renal tubular injury and apoptosis. Pharmacological inhibition of MLL1 activity with MI503 to disrupt the interaction between MLL1 with Menin further increased Scr and BUN levels, enhanced expression of neutrophil gelatinase associated lipocalin and kidney injury molecule-1, and induced more apopt...
Source: Am J Physiol Renal P... - September 21, 2023 Category: Urology & Nephrology Authors: Xiying Hou Binbin Cui Andong Qiu Na Liu Shougang Zhuang Source Type: research
A nationwide survey of MYH9-related disease in Japan
ConclusionOur study demonstrated no beneficial effect of RAS inhibitors on kidney function in patients withMYH9-RD, indicating the need for further studies with more patients. All modalities of KRT are feasible options forMYH9-RD patients who progress to ESKD, with adequate attention to bleeding complications.
Source: Clinical and Experimental Nephrology - September 21, 2023 Category: Urology & Nephrology Source Type: research
Re: Post-chemotherapy robot-assisted retroperitoneal lymph node dissection for metastatic germ cell tumors: safety and perioperative outcomes. World J Urol. 2023 Jul 28. doi: 10.1007/s00345-023 –04536-3
Source: World Journal of Urology - September 21, 2023 Category: Urology & Nephrology Source Type: research
